Because of the impact Adobe have had on many peoples consious, such as the words "is this photoshoped", its no wonder, why many people live in a bubble, believing nothing "big and important" are made with other computer software, other than those from Adobe.
Well the people behind "South Park" uses CorelDRAW to make their 2D illustrations, and then bring it into Maya to animate it. Neither CorelDRAW or Maya is Adobe software. This said, remember software are TOOLS to work with. Its the person holding and using the tool who creates the art. And CorelDRAW and Maya are very powerfull tools to work with. Have fun creating whatever tool you use. Here is the interface of CorelDRAW.
Illustrator & artist